Drug Discovery

Applications Overview
Assisted Reproductive Technology
Live Cell Imaging
Drug Discovery
CT-2000 Live Cell Imaging System
Drug Discovery

In the area of drug discovery, integrated microfluidics and live cell imaging systems hold great promise for key areas, such as the preclinical testing of drugs in live cells and the screening of compounds. These platforms feature automated perfusion of media, precise environmental controls, and the administration of drugs without the disruption of cells. This allows critical quantitative and qualitative information to be efficiently captured; data otherwise inaccessible using most conventional approaches.

Induction of Apoptosis Using an Active Microfluidic System for Microscopy

Drug-induced apoptosis experiments performed in 96-well plates have significant requirements; the attention of personnel during the entire time-course, potential well-to-well variability, and expensive use of reagents and cells. The cellTRAY Live Cell Imaging System allows real-time monitoring, where automated precise control of the microenvironment and data capture are required.

High-Throughput Live Cell Screening

Screening of siRNA libraries is complex and expensive, involving a large number of well plate assays, with a fluorescent, or colorimetric end point readout. The cellTRAY can be used as a more effective microscope-based screening technology, spotted with up to 7680 different siRNA oligonucleotides or cDNA encoding shRNA constructs.

A Bright Field Cell Viability Assay in the cellTRAY® Live Cell Imaging System

In vitro model systems have been proven useful in screening for inhibitory or stimulatory compounds that affect specific enzyme systems or affect the general process of cell death and apoptosis. A protocol has been developed for performing cell viability assays with the vital stain Trypan Blue, using Nanopoint's cellTRAY Live Cell Imaging System.
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